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In patients with RH, office or home BP is typically less than 140/90 mm Hg. Home BPs are often higher than office BPs because of underlying circadian BP variability, white-coat effect, and the use of different BPs at home and in the office, which can be difficult to predict.^{2, 3, 5} Each individual has a unique circadian pattern of BP that is independent of the time of day; during sleep, ambulatory BP can be lower than office BP. A non-white patient can have a higher BP reading at home than at the doctor’s office.¹⁴⁶ RH can be differentiated from white-coat RH by a decrease in office BPs and self-monitored BPs and a decrease in home BPs during prolonged follow-up.¹

The relationship between diet, BP and cardiovascular disease (CVD) is complex, multifactorial, and mainly observational. Higher sodium consumption has been associated with higher BP values and increased risk of CVD, whereas limited evidence suggests that lower sodium intake is associated with increased risk of CVD.¹⁵³ Experimental studies of sodium-restricted diets in a controlled setting with individuals with true RH demonstrate that a 4- to 6-g (151- to 187-mmol) loss in daily sodium intake (encompassing daily intake of 1.52 to 2.02 g dietary sodium and the loss of 0.6 to 0.72 g sodium during sweat and metabolic losses) has the potential to reduce BP to normal levels and to normalize sympathetic nervous system activity, and also normalize aldosterone (ALDO) secretion in patients with resistant hypertension.^{58, 154, 355} In a study of 15 patients with RH (average age, 58 years; 12 men, 3 women) on optimal doses of diuretics, beta blockers, and angiotensin-converting enzyme inhibitors, switching the patient’s usual diet to a reduced-sodium diet (2 g/d sodium, 40 mmol/d potassium) led to a 9-mm Hg reduction in office SBP after 1 week.⁵⁸ Another study of 15 patients (average age, 55 years; 12 men, 3 women) with RH on optimal doses of ACE inhibitors, beta blockers, and diuretics and potassium-sparing diuretics demonstrated a reduction of SBP of 14.5mm Hg after switching to a low-sodium (50 mmol/d sodium, 86 mmol/d potassium) diet for 4 weeks.⁵⁸ Although these small studies demonstrate the feasibility of rapidly instituting a reduced-sodium diet with BP control, this was not a randomized trial. Nevertheless, dietary sodium restriction appears to be effective for BP control in patients with RH.

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In Office on Windows, you can use File > Open to open a document. You can also right-click a document and select Open with Office Document Setup to automatically install the file.

The online collaboration features in Office 365 enable you to work online with others on documents, e-mails, and comments. For example, one user can view the online version of the document, and another user can make comments in the document. These comments remain in sync across the two users. In addition, Office 365 Apps for Windows and Office Online enable you to create, view, and interact with documents online from any browser on any device. If you want to take advantage of these collaboration features, you must have the right permissions to do so. To learn more about the permissions available, see Permissions for Office Online .

If you’re planning on setting up the required Microsoft features (for example, setting up your Microsoft Account, My People, or information) manually when you first install Office LTSC 2021, you need to set a few things up when you first install Office LTSC 2021. These settings need to be made in the local machine you’re installing on. The steps that you need to perform might differ based on your local machine environment. Your local computer is:

Once you’ve done the above setup, you can then set up the required Microsoft features (for example, setting up your Microsoft Account, My People, or information) manually when you first install Office LTSC 2021. For example, you may want to use My People.

Your Microsoft Account and information like your security settings and your name will be saved automatically when you install Office LTSC 2021. For example, you may want to use your Microsoft Account in My People. If you want to change any of this info, you need to update your settings at this web site (https://manage.office.com). After you’re logged in to your Microsoft Account, click the Settings link on the left-hand side. From there, click the option to change your Microsoft account name or password, or your security settings.

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Before you download and install Office LTSC 2021 on your computer, you must activate it. You can activate Office LTSC 2021:

Through the Office 365 portal or any client with a Microsoft account.
Through the Command-line or using a client that supports PowerShell.

Before you download and install Office LTSC 2021.04, you must activate it.

Through the Office 365 portal or any client with a Microsoft account.
Through the Command-line or using a client that supports PowerShell.

You can install Office LTSC 2021 directly from the Office CDN. Or, you can download the installation files from the Office CDN to a location on your local network, such as a shared folder, and install Office LTSC 2021 from that location. You can use different methods for different sets of devices in your organization. Whichever method you choose, you use the ODT.

Microsoft is deprecating SHA-1, an industry standard encryption algorithm that is used to protect the integrity of the code and content we deliver to you. As of January 29, 2017, we are no longer supporting SHA-1. To ensure the integrity of the code that we deliver, we have signed our Microsoft Office ISO images with a code-signing certificate. This change has been made for compatibility purposes. The files you see on the Office CDN are signed and verified to ensure they contain a safe and trustworthy copy of the Microsoft Office ISO.

Office LTSC 2021 allows you to create a new migration or import/export project or directly create a media content from a file that has not been associated with an MsoDoc type. This feature can be used to obtain media content from any version of Office.

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